Cardiorespiratory effects of protamine after cardiopulmonary bypass in man.
نویسندگان
چکیده
منابع مشابه
Complement activation during cardiopulmonary bypass by heparin-protamine interaction.
Circulating concentrations of split products of the third complement factor (C3c and C3d) were measured in five patients before, during and after cardiopulmonary bypass. In all patients, C3d concentrations increased significantly in samples obtained after the administration of protamine sulphate. Similarly, circulating C3c was seen only in those samples obtained immediately after protamine admi...
متن کاملProtamine dosage effects on complement activation and sonoclot coagulation analysis after cardiac surgery
Background: An optimal dosage and infusion regime for protamine reversal of heparin after cardiopulmonary bypass is important. Methods: Protamine dosages of either 2mg/kg or 4mg/kg bodyweight were compared in 40 patients after first time coronary arterial bypass grafting. Protamine was infused with a syringe driver over 20 minutes. Arterial blood sampling was performed prior to and during surge...
متن کاملSuccessful cardiopulmonary bypass in diabetics with anaphylactoid reactions to protamine.
Two insulin dependent diabetics with previous anaphylactic like (anaphylactoid) reactions to protamine underwent successful cardiopulmonary bypass for coronary artery surgery. Platelet concentrates instead of protamine were used to neutralise their systemic heparinisation. In both cases the anaphylactoid reactions first became apparent after administration of protamine sulphate at the end of ca...
متن کاملHeparin-induced thrombocytopenia and cardiopulmonary bypass: anticoagulation with unfractionated heparin and the GPIIb/IIIa inhibitor tirofiban and successful use of rFVIIa for post-protamine bleeding due to persistent platelet blockade.
Heparin-induced thrombocytopenia was diagnosed in a 50-year-old man on day 5 after cardiac surgery (aorto-coronary bypass and mitral valve replacement). He required redo (para-prosthesis leak) on day 13. The cardiopulmonary bypass (CPB) was performed with unfractionated heparin (UFH) and the platelet glycoprotein (GP) IIb/IIIa inhibitor tirofiban. Post-protamine bleeding likely due to documente...
متن کاملSuccessful Treatment of Anaphylactic Shock after Protamine Administration-Report of a Case
A 43-year-old man, with a past history of hypertension without regular medical control, presented to our hospital with intermittent chest tightness and shortness of breathing about one day. At emergent department, the blood pressure was 180/110 mmHg, and pulse rate was 78 beats per minute. Troponin I was 3.19 ng/ml. EKG showed V1-V4 ST elevation. Coronary angiography showed near total occlusion...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Thorax
دوره 29 5 شماره
صفحات -
تاریخ انتشار 1974